evidencece for retinal care
Founded and chaired by Dr. Varun Chaudhary, OphthoEvidence is an international collaboration of retinal specialists, clinician-scientists, methodologists, and clinical trialists dedicated to advancing evidence-informed retinal care through rigorous evidence synthesis.
The program generates and synthesizes high-quality evidence through systematic reviews, meta-analyses, and innovative evidence synthesis methodologies, evaluating treatments, biomarkers, imaging and emerging technologies in retinal disease.
These evidence synthesis provide the scientific foundation for clinical guidance, education, research and knowledge translation initiatives that improve retinal care internationally.
Comparative Effectiveness
Evaluating benefits and harms of macular therapies
We synthesize evidence across randomized and observational studies to compare the effectiveness and safety of available treatments for macular diseases. Analyses are conducted using established systematic review and meta-analytic methods to support balanced interpretation of treatment options.
Imaging & Prognostic Biomarkers
Assessing the clinical value of imaging features
We evaluate the prognostic relevance of imaging biomarkers derived from modalities such as OCT and fundus imaging, including their association with disease progression, treatment response, and visual outcomes.
AI & Analytical Methods
Evaluating emerging analytical approaches in macular care
We assess the performance and applicability of artificial intelligence and data-driven models in diagnosis, prognosis, and treatment guidance, with attention to methodological quality and generalizability.
Evidence Gaps & Research Direction
Identifying priorities for future investigation
We identify areas of uncertainty and inconsistency in the literature to inform future clinical trials and research priorities.
RETINA Initiative (Journal Eye)
Scholarly work in evidence synthesis methodology
The program contributes to academic discussions on evidence synthesis methodology and its application in retina through peer-reviewed publications, including work presented in the journal Eye.
Methods & Approach
Structured, Transparent, and Reproducible
- Systematic review and meta-analysis
- Risk-of-bias assessment using established frameworks
- Predefined protocols and reproducible workflows
- Quantitative and qualitative synthesis
